Invention Grant
- Patent Title: Methods and compositions targeting glucocorticoid signaling for modulating immune responses
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Application No.: US16396461Application Date: 2019-04-26
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Publication No.: US11957695B2Publication Date: 2024-04-16
- Inventor: Ana Carrizosa Anderson , Asaf Madi , Nandini Acharya , Vijay K. Kuchroo , Aviv Regev
- Applicant: The Broad Institute, Inc. , Massachusetts Institute of Technology , The Brigham and Women's Hospital, Inc.
- Applicant Address: US MA Cambridge
- Assignee: The Broad Institute, Inc.,Massachusetts Institute of Technology,The Brigham and Women's Hospital, Inc.
- Current Assignee: The Broad Institute, Inc.,Massachusetts Institute of Technology,The Brigham and Women's Hospital, Inc.
- Current Assignee Address: US MA Cambridge; US MA Cambridge; US MA Boston
- Agency: Johnson, Marcou, Isaacs & Nix, LLC
- Agent F. Brent Nix, Esq.; Michael B. Scher, Esq.
- Main IPC: A61K31/573
- IPC: A61K31/573 ; A61K35/17 ; A61K38/20 ; A61K45/06 ; A61P35/00
Abstract:
The subject matter disclosed herein is generally directed to modulating T cell dysfunctional and effector states by modulating glucocorticoid and IL-27 signaling. The invention further relates to modulating immune states, such as CD8 T cell immune states, in vivo, ex vivo and in vitro. The invention further relates to diagnostic and screening methods.
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