Invention Grant
- Patent Title: Non-natural NKG2D receptors that do not directly signal the cells to which they are attached
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Application No.: US16674705Application Date: 2019-11-05
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Publication No.: US11957714B2Publication Date: 2024-04-16
- Inventor: Kaman C. Kim , David W. Martin, Jr. , Steven Williams
- Applicant: XYPHOS BIOSCIENCES INC.
- Applicant Address: US CA South San Francisco
- Assignee: XYPHOS BIOSCIENCES INC.
- Current Assignee: XYPHOS BIOSCIENCES INC.
- Current Assignee Address: US CA South San Francisco
- Agency: MARSHALL, GERSTEIN & BORUN LLP
- Main IPC: C07K14/705
- IPC: C07K14/705 ; A61K35/17 ; A61K47/64 ; C07K19/00 ; C12N5/07 ; C12N5/078

Abstract:
The present disclosure relates to non-natural NKG2D receptors attached to mammalian cell surfaces wherein the non-natural receptors do not directly signal or directly activate the cell when the receptor is bound by cognate non-natural α1-α2 domains of NKG2D ligands modified to specifically bind the non-natural NKG2D receptors. The non-natural α1-α2 domains of NKG2D ligands may be attached to heterologous atoms or molecules including polypeptides, in some embodiments cytokines or modified cytokines, antibodies or fragments of antibodies.
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