Invention Grant
- Patent Title: HNQO1-activatable fluorescent probe for imaging cancer cells in-vitro and in-vivo
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Application No.: US16950107Application Date: 2020-11-17
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Publication No.: US11957766B2Publication Date: 2024-04-16
- Inventor: Kalkunte S. Srivenugopal , Surendra R. Punganuru
- Applicant: Texas Tech University System
- Applicant Address: US TX Lubbock
- Assignee: TEXAS TECH UNIVERSITY SYSTEM
- Current Assignee: TEXAS TECH UNIVERSITY SYSTEM
- Current Assignee Address: US TX Lubbock
- Agency: Chalker Flores, LLP
- Agent Edwin S. Flores; Daniel J. Chalker
- Main IPC: A61B5/00
- IPC: A61B5/00 ; A61B8/00 ; A61B10/00 ; A61K49/00 ; C07C255/38 ; C07C255/44 ; C12Q1/32 ; G01N33/574 ; G01N33/58
Abstract:
The present invention includes a probe, an assay, a method of detecting, a human NAD(P)H quinone oxidoreductase-1 (hNQO1) enzyme activity with a fluorescent probe comprising a quinone propionic acid (QPA) conjugated to dicyanoisophorone (DCP), wherein the hNQO1 reduces the probe to releases a fluorescent DCP, and a method of making the same.
Public/Granted literature
- US20210154330A1 HNQO1-ACTIVATABLE FLUORESCENT PROBE FOR IMAGING CANCER CELLS IN-VITRO AND IN-VIVO Public/Granted day:2021-05-27
Information query
