Invention Grant
- Patent Title: Inhibitors of bacterial glutaminyl cyclases for use in the treatment of periodontal and related diseases
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Application No.: US16971618Application Date: 2019-02-22
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Publication No.: US11958871B2Publication Date: 2024-04-16
- Inventor: Christian Jäger , Linda Liebe , Daniel Ramsbeck , Miriam Linnert , Stefanie Geissler , Anke Piechotta , Diane Meitzner , Holger Cynis , Mirko Buchholz
- Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
- Applicant Address: DE Munich
- Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
- Current Assignee: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
- Current Assignee Address: DE Munich
- Agency: Seed IP Law Group LLP
- Priority: EP 158343 2018.02.23
- International Application: PCT/EP2019/054476 2019.02.22
- International Announcement: WO2019/162458A 2019.08.29
- Date entered country: 2020-08-20
- Main IPC: C07F15/02
- IPC: C07F15/02 ; A61P31/04 ; C07D471/04
Abstract:
The present invention relates to novel compounds which are particularly useful as inhibitors of bacterial glutaminyl cyclases (bacQC); pharmaceutical compositions comprising such compounds; compounds and/or pharmaceutical compositions for use in methods for treatment, in particular for use in the treatment of periodontitis and related conditions; as well as to crystals comprising bacterial glutaminyl cyclases, methods for identifying candidate compounds which may associate with the binding pocket of a bacQC and/or are bacQC inhibitors.
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