Invention Grant
- Patent Title: Integration sites and uses thereof
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Application No.: US16492950Application Date: 2018-03-14
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Publication No.: US11959093B2Publication Date: 2024-04-16
- Inventor: Ling-Jie Kong , Ruby Yanru Tsai , Xiuling Chi
- Applicant: APPLIED STEMCELL, INC.
- Applicant Address: US CA Milpitas
- Assignee: APPLIED STEMCELL, INC.
- Current Assignee: APPLIED STEMCELL, INC.
- Current Assignee Address: US CA Milpitas
- Agency: Jun He Law Offices P.C
- Agent James J. Zhu
- International Application: PCT/US2018/022274 2018.03.14
- International Announcement: WO2018/175153A 2018.09.27
- Date entered country: 2019-09-11
- Main IPC: C12N15/79
- IPC: C12N15/79 ; C07H21/04 ; C12N15/113 ; C12N15/90 ; C07H21/02 ; C12N15/63 ; C12N15/85 ; C12N15/86
Abstract:
The present disclosure provides compositions and methods for enhanced expression of exogenous genes in eukaryotic cells. The method involves introducing into a mammalian cell an exogenous nucleic acid. wherein the exogenous nucleic acid intearates into a locus of the genome that comprises an extended methylation-free CpG island. Also provided are chromosomal loci, sequences for enhanced and stable expression of exogenous genes.
Public/Granted literature
- US20200017884A1 NOVEL INTEGRATION SITES AND USES THEREOF Public/Granted day:2020-01-16
Information query
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