Invention Grant
- Patent Title: Method of quantifying lysergic acid diethylamide (LSD) and 2,3-dihydro-3-hydroxy-2-oxo lysergide (O-H-LSD) in human plasma
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Application No.: US17506119Application Date: 2021-10-20
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Publication No.: US11959929B2Publication Date: 2024-04-16
- Inventor: Matthias E. Liechti , Urs Philipp Duthaler
- Applicant: Universitatsspital Basel
- Applicant Address: CH Basel
- Assignee: Universitätsspital Basel
- Current Assignee: Universitätsspital Basel
- Current Assignee Address: CH Basel
- Agency: Kohn and Associates PLLC
- Main IPC: G01N33/94
- IPC: G01N33/94 ; A61K31/48 ; G01N30/72 ; G01N33/487
Abstract:
A method of measuring and identifying LSD and its major metabolite O-H-LSD, by obtaining a sample from an individual, and measuring, identifying, and quantifying LSD and O-H-LSD in the sample by performing a LC-MS/MS analysis. A method of treating and monitoring individuals taking LSD, by administering a microdose of LSD, a prodrug of LSD, or an analog of LSD to the individual, monitoring the individual by obtaining a sample from an individual and measuring and identifying the analytes in the sample by performing a LC-MS/MS analysis, and adjusting the microdose based on the amount of LSD quantified in the LC-MS/MS analysis. A method of adjusting dosing of LSD, by administering a microdose of LSD, a prodrug of LSD, or an analog of LSD to the individual, and adjusting the microdose based on blood concentration analytics.
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