Machine vision systems and methods for automatically generating machine vision job(s) based on region of interests (ROIs) of digital images are disclosed herein. The systems and methods comprise configuring a machine vision tool for capturing an image ID depicted in training images and labeling each training image to indicate a success or failure status of an object depicted by the training images. Candidate image feature(s) are extracted from the training images for generation of candidate ROI(s). A training set of ROIs are selected from the candidate ROI(s) and are designated as an included or excluded ROIs. The training set of ROIs and the training images are used to train a vision learning model configured to output a machine vision job deployable to an imaging device that implements the machine vision job to detect the success or failure statuses of additional image(s) depicting the object.