Systems and methods related to transferring (e.g., large) files over a network are disclosed. In at least one embodiment, a client-server framework establishes a QUIC connection between a server application and a client application. Source files are processed by the server application to divide the source files into a number of chunks. Differential file transfer can be implemented between the client application and the server application by comparing metadata for chunks of the source file with metadata of local chunks of a destination file already stored in a local storage associated with the client application. Missing chunks can be requested from the server application and transferred to the client application using HTTP/3 messages.