A method and system for aligning exposure center points of multiple cameras in a VR system are provided. The method includes: acquiring image data of a first type frame according to a preset frame rate; adjusting VTS data of the first type frame, the VTS data changing with the change of the exposure parameters so as to fix a time interval between an exposure center point of the first type frame and an FSIN synchronization signal in a VR system; acquiring image data of a second type frame according to the preset frame rate; and adjusting VTS data of the second type frame according to the VTS data of the first type frame, and fixing a time interval between an exposure center point of the second type frame and the FSIN synchronization signal so as to complete the alignment of exposure center points of the cameras.