A method in a User Equipment (UE) configured with Discontinuous Reception (DRX) and a method in a network node for Downlink (DL) scheduling of the UE. The UE is further configured with Semi Persistent Scheduling (SPS) which reduces the latency in Uplink (UL) transmission. The network node monitors a receipt of UL data in any of the SPS resources granted to the UE, a Wake-up grant or assignment is sent on the Physical Downlink Control Channel (PDCCH), and a HARQ-information is sent in response to the received UL data. The Wake-up grant/assignment triggers a drx-Inactivity timer to run in the UE. While the UE is DRX active, the network node may schedule a DL data transmission and send a DL assignment and the DL data to the UE.