A robotic suture knot tying system includes a first robotic arm, a second robotic arm, a suturing device including a suturing end effector operatively coupled to the first robotic arm, and a suture handling device operatively coupled to the second robotic arm. The system also includes a control system operatively coupled to the first robotic arm, the second robotic arm, the suturing device, and the suture handling device and configured to control operation thereof to cooperatively perform a suture knot tying procedure on a patient.