Invention Grant
- Patent Title: Anti-tumor polypeptide Bax-BH3, fluorescent polymeric nanomicelle, preparation method and use thereof
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Application No.: US17812934Application Date: 2022-07-15
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Publication No.: US11963997B2Publication Date: 2024-04-23
- Inventor: Li Xu , Yi Guo , Sijun Huang , Xi Zhang , Mingming Zhang
- Applicant: Jilin University
- Applicant Address: CN Changchun
- Assignee: Jilin University
- Current Assignee: Jilin University
- Current Assignee Address: CN
- Agency: Lerner David LLP
- Priority: CN 2110823372.4 2021.07.21
- Main IPC: A61K47/34
- IPC: A61K47/34 ; A61K38/17 ; A61K47/32 ; A61K49/00 ; A61P35/00
Abstract:
The present disclosure provides an anti-tumor polypeptide Bax-BH3, a fluorescent polymeric nanomicelle, a preparation method and use thereof, belonging to the technical field of medicines. The anti-tumor polypeptide Bax-BH3 has an amino acid sequence set forth in SEQ ID No: 1; the fluorescent polymeric nanomicelle includes the anti-tumor polypeptide Bax-BH3 and a polymer carrier; and the polymer carrier is a block copolymer RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA)). In the present disclosure, the anti-tumor polypeptide Bax-BH3 has desirable biocompatibility and biological activity; and the fluorescent polymeric nanomicelle encapsulates the anti-tumor polypeptide Bax-BH3 by the block copolymer RGD-PHPMA-b-Poly(MMA-alt-(Rhob-MA)), with high encapsulation rate and drug loading, and good release performance.
Public/Granted literature
- US20230037813A1 ANTI-TUMOR POLYPEPTIDE Bax-BH3, FLUORESCENT POLYMERIC NANOMICELLE, PREPERATION METHOD AND USE THEREOF Public/Granted day:2023-02-09
Information query
IPC分类:
