Invention Grant
- Patent Title: Methods and compositions for heterologous repRNA immunizations
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Application No.: US17645556Application Date: 2021-12-22
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Publication No.: US11964007B2Publication Date: 2024-04-23
- Inventor: Ronald Vogels , Marijn Van Der Neut Kolfschoten , Darrell J. Irvine , Ron Weiss , Ely Blanton Porter , Mariane Bandeira Melo , Tasuku Kitada
- Applicant: Janssen Vaccines & Prevention B.V. , Massachusetts Institute of Technology
- Applicant Address: NL MA Leiden
- Assignee: Janssen Vaccines & Prevention B.V.,Massachusetts Institute of Technology
- Current Assignee: Janssen Vaccines & Prevention B.V.,Massachusetts Institute of Technology
- Current Assignee Address: NL Leiden; US MA Cambridge
- Agency: Ice Miller LLP
- Main IPC: A61K48/00
- IPC: A61K48/00 ; A61K39/00 ; A61K39/12 ; C12N15/11 ; C12N15/86
Abstract:
Compositions and methods are described for inducing an immune response against an immunogen in humans. The induced immune response is obtained by administering a heterologous prime-boost combination of an in vitro transcribed (IVT) self-replicating RNA (repRNA) and an adenovirus vector. The compositions and methods can be used to provide a protective immunity against a disease, such as a viral infection or a cancer, in humans.
Public/Granted literature
- US20220111033A1 Methods and Compositions for Heterologous repRNA Immunizations Public/Granted day:2022-04-14
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