Disclosed is an integrated sealed micro-mesh nebulization module, which includes: an nebulization device and a nozzle mechanism disposed on the nebulization device, the nozzle mechanism disposed on the nebulization device is detachably connected with the nebulization device; the nebulization module comprises an annular base, a lower shell disposed in the annular base, an upper shell disposed on the lower shell, a micro-mesh nebulization sheet disposed on the lower shell, a first sealing ring and a second sealing ring respectively disposed on both sides of the micro-mesh nebulization sheet, and a metal contact disposed between the lower shell and the upper shell, with one end connected with the micro-mesh nebulization sheet through a wire, and the other end extending to an exterior of the lower shell and connected with an external driving circuit.