Invention Grant
- Patent Title: Substituted bicyclic compounds useful as T cell activators
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Application No.: US17130022Application Date: 2020-12-22
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Publication No.: US11964973B2Publication Date: 2024-04-23
- Inventor: Robert G. Gentles , Upender Velaparthi , Min Ding , Richard E. Olson , Scott W. Martin , Saumya Roy , Prasada Rao Jalagam , Jayakumar Sankara Warrier , Louis S. Chupak , Denise Christine Grunenfelder
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: Bristol-Myers Squibb Company
- Current Assignee: Bristol-Myers Squibb Company
- Current Assignee Address: US NJ Princeton
- Agent Gary Greenblatt
- Priority: IN 1911053552 2019.12.23
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D401/04

Abstract:
Disclosed are compounds of Formula (I):
or a salt thereof, wherein: X is CR6 or N; Y is CR3 or N; R1, R2, R3, R4, R5, R6, R7, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
or a salt thereof, wherein: X is CR6 or N; Y is CR3 or N; R1, R2, R3, R4, R5, R6, R7, and m are defined herein. Also disclosed are methods of using such compounds to inhibit the activity of one or both of diacylglycerol kinase alpha (DGKα) and diacylglycerol kinase zeta (DGKζ), and pharmaceutical compositions comprising such compounds. These compounds are useful in the treatment of viral infections and proliferative disorders, such as cancer.
Public/Granted literature
- US20210188845A1 SUBSTITUTED BICYCLIC COMPOUNDS USEFUL AS T CELL ACTIVATORS Public/Granted day:2021-06-24
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