Invention Grant
- Patent Title: Compositions and methods for regulating proteins and nucleic acids activities
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Application No.: US16776503Application Date: 2020-01-29
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Publication No.: US11965159B2Publication Date: 2024-04-23
- Inventor: Amit Choudhary , Kurt Cox , Hari Subramanian , Elisa Franco
- Applicant: THE BROAD INSTITUTE, INC. , THE BRIGHAM AND WOMEN'S HOSPITAL, INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
- Applicant Address: US MA Cambridge
- Assignee: The Broad Institute, Inc.,The Brigham and Women's Hospital, Inc.,The Regents of the University of California
- Current Assignee: The Broad Institute, Inc.,The Brigham and Women's Hospital, Inc.,The Regents of the University of California
- Current Assignee Address: US MA Cambridge; US MA Boston; US CA Oakland
- Agency: Johnson, Marcou, Isaacs & Nix, LLC
- Agent F. Brent Nix, Esq.
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K31/00 ; A61K38/46 ; C12N9/22 ; C12N15/113 ; C12N15/67
Abstract:
Compositions and methods for conditionally regulating activities of CRISPR-Cas systems. In some embodiments, the methods comprise providing an inactive guide RNA comprising a regulatory domain bound by a lock nucleic acid different from the guide RNA; and displacing the lock nuclei acid from the regulatory domain by a trigger nucleic acid, thereby activating the guide RNA, wherein the activated guide RNA forms a complex with a Cas enzyme.
Public/Granted literature
- US20200239879A1 COMPOSITIONS AND METHODS FOR REGULATING PROTEINS AND NUCLEIC ACIDS ACTIVITIES Public/Granted day:2020-07-30
Information query
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