Invention Grant
- Patent Title: Targeted DNA demethylation method, fusion protein and application thereof preliminary class
-
Application No.: US18155097Application Date: 2023-01-17
-
Publication No.: US11965187B2Publication Date: 2024-04-23
- Inventor: Xi-Yong Yu , Yu-Guang Zhu , Ao Shen , Ling-Min Zhang , Ji-Shuo Chang
- Applicant: Guangzhou Medical University , GMU New Drug Development Co., Ltd.
- Applicant Address: CN Guangzhou
- Assignee: GUANGZHOU MEDICAL UNIVERSITY,GMU NEW DRUG DEVELOPMENT CO., LTD.
- Current Assignee: GUANGZHOU MEDICAL UNIVERSITY,GMU NEW DRUG DEVELOPMENT CO., LTD.
- Current Assignee Address: CN Guangzhou; CN Guangzhou
- Agent Zhigang Ma
- Priority: CN 2210050631.9 2022.01.17
- Main IPC: C12N9/22
- IPC: C12N9/22 ; A61K48/00 ; C12N15/85
Abstract:
A targeted DNA demethylation method (Mini-CRISD) and a fusion protein used in the method are provided. The Mini-CRISD method can targets delivery of demethylation activity through engineered miniature dCjCas9 to deliver engineered miniature ROS1 demethylation effector to specific DNA sequences and/or specific genomic locations (such as CpG islands) to achieve targeted demethylation of specific DNA.
Public/Granted literature
- US20230287374A1 TARGETED DNA DEMETHYLATION METHOD, FUSION PROTEIN AND APPLICATION THEREOF Public/Granted day:2023-09-14
Information query
