A method and a system for simulating contact and interaction between a support member and a chamber surrounding rock mass are provided in the application. The method includes: obtaining a support scheme of a roadway to be simulated, dividing the roadway to be simulated based on the support scheme to obtain several roadway sections; obtaining physical and mechanical parameters of each rock stratum in each roadway section and an occurrence state of the roadway surrounding rock; constructing particle flow numerical models corresponding to the roadway section; through the particle flow numerical models of every two adjacent roadway sections, obtaining a particle flow meso-structural evolution model of the roadway to be simulated; obtaining meso-mechanical parameters of the roadway to be simulated based on the particle flow numerical models, calibrating the meso-mechanical parameters through the physical and mechanical parameters, establishing the particle flow meso-structural evolution model of the roadway to be simulated.