A tissue analysis system may include an ultrasound device to stimulate tissue with ultrasound waves causing the tissue to vibrate and produce a vibration signature, a vibration detector configured to detect the vibration signature, and a signal analysis processor. The signal analysis processor may be configured according to computer-executable instructions for accessing a signature library storing a plurality of vibration signatures each linked to one of a plurality of known tissues having a known identity, comparing the vibration signature of the tissue with the stored vibration signatures of the signature library, determining if a match between the vibration signature of the tissue and a stored vibration signature of the signature library is present and, if the match is present, determining an identity of the tissue based on the known identity of the known tissue having the matching stored vibration signature.