Clock generation circuit generating multiple divided signals satisfying respective desired offsets. A phase locked loop (PLL) is used to generate a PLL output having a frequency which is a desired multiple of that of a reference clock. The circuit divides the PLL output by a corresponding divisor to generate a corresponding divided signal, wherein each divided signal is offset from a common reference by at least an associated desired time offset. The common reference is timed with respect to the reference clock when the reference clock is available and with respect to a time reference signal otherwise. This arrangement is extended to use the internal time reference signal even for the cases where the reference clock is present by blocking the reference clock while the output systems across PLLs are aligned using the internal time reference signal to ensure desired offsets across different PLLs with a small uncertainty.