An information handling system communicates with external devices, such as a docking station, through a multi-protocol streaming cable, such as USB 3.0 (or greater) cable having a USB data protocol, a DisplayPort graphics protocol and a power transfer protocol. Upon detection of excessive errors at the cable, the multi-protocol stream is adjusted to maintain errors within an acceptable range and prioritize information transferred through one of the protocols. Adjustments may include changes to the number of data lanes assigned to each protocol, changes to the rate at which information is transferred with each protocol and changes to power transfer.