Invention Grant
- Patent Title: Laser-speckle contrast imaging system and method
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Application No.: US18550776Application Date: 2022-03-21
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Publication No.: US11974812B2Publication Date: 2024-05-07
- Inventor: Dwani Patel , Al Hafeez Dhalla , Christian B. Viehland , Daniel M. Lipinski
- Applicant: The Medical College of Wisconsin, Inc. , Coherence Consulting LLC
- Applicant Address: US WI Milwaukee
- Assignee: The Medical College of Wisconsin, Inc.,Coherence Consulting LLC
- Current Assignee: The Medical College of Wisconsin, Inc.,Coherence Consulting LLC
- Current Assignee Address: US WI Milwaukee; US NC Durham
- Agency: Quarles & Brady LLP
- Agent Yakov Sidorin
- International Application: PCT/US2022/021160 2022.03.21
- International Announcement: WO2022/204034A 2022.09.29
- Date entered country: 2023-09-15
- Main IPC: A61B3/12
- IPC: A61B3/12 ; A61B3/14

Abstract:
Laser-Speckle Contrast imaging apparatus configured to assess and quantify motion associated with an object and, in a specific case of an eye—retinal vascular anatomy and hemodynamics and generate substantially contrast-free maps of retinal blood flow over a wide field-of-view at up to 590 fps and under short exposure durations (>50 μs), is applicable for diagnosis, study, and management of neurodegenerative conditions (i.e. mild cognitive impairment and Alzheimer's disease) and systemic cardiovascular diseases (i.e. athero- and arteriosclerosis, coronary artery occlusion, and hypertension). The apparatus employs a) a set of apertures substantially blocking light, delivered from a source of light to an illumination arm of the apparatus, from impinging onto an axial point of the front surface of the lens of the illumination arm, and b) polarization gating between the illumination and light-collecting arms of the apparatus. In one implementation, the apparatus is configured to allow for irradiation of the object with an optical field a degree of coherence and/or spectral content of which are varied delivered through the same optical train including the set of apertures.
Public/Granted literature
- US20240032790A1 Laser-Speckle Contrast Imaging System and Method Public/Granted day:2024-02-01
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