Systems and methods for mission-based path modifications are presented herein. One or more processors may be coupled with memory and housed in a vehicle. The one or more processors may receive data indicative of an issue with at least one function of the vehicle during a mission defined by a type of cargo and a flight path comprising a plurality of segments. The one or more processors may determine, responsive to the issue with the at least one function, an action to perform for the vehicle based on the issue, a current segment of the plurality of segments, and the mission. The one or more processors may execute, during the current segment or a subsequent segment of the plurality of segments, the action on the vehicle.