The present disclosure provides various embodiments of methods for intelligent active speaker identification and information handling systems (IHSs) utilizing such methods. In general, the methods disclosed herein may be used to accurately identify an active speaker in a communication session with an application or an IHS, regardless of whether the active speaker is alone, in a group environment, or using someone else's system or login to participate in the communication session. The methods disclosed herein may use voice processing technology and one or more voice identification databases (VIDs) to identify the active speaker in a communication session. In some embodiments, the disclosed methods may display the identity of the active speaker to other users or participants in the same communication session. In other embodiments, the disclosed methods may dynamically switch between user profiles or accounts during the communication session based on the identity of the active speaker.