Invention Grant
- Patent Title: Bicistronic chimeric antigen receptors and their uses
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Application No.: US16613187Application Date: 2018-05-15
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Publication No.: US11980640B2Publication Date: 2024-05-14
- Inventor: Haiying Qin , Crystal L Mackall , Terry J. Fry
- Applicant: The United States of America,as represented by the Secretary,Department of Health and Human Services
- Applicant Address: US MD Bethesda
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US MD Bethesda
- Agency: Leydig, Voit & Mayer
- International Application: PCT/US2018/032809 2018.05.15
- International Announcement: WO2018/213337A 2018.11.22
- Date entered country: 2019-11-13
- Main IPC: A61K35/17
- IPC: A61K35/17 ; A61P35/00 ; C07K14/395 ; C07K14/725 ; C07K16/28 ; C12N15/85
Abstract:
An embodiment of the invention provides bicistronic chimeric antigen receptor (CAR) amino acid constructs. Nucleic acids, recombinant expression vectors, host cells, populations of cells, and pharmaceutical compositions relating to the CAR constructs are disclosed. Methods of detecting the presence of cancer in a mammal and methods of treating or preventing cancer in a mammal are also disclosed. Methods of making the CAR constructs are disclosed.
Public/Granted literature
- US20200147134A1 BICISTRONIC CHIMERIC ANTIGEN RECEPTORS AND THEIR USES Public/Granted day:2020-05-14
Information query
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