A filter cartridge for an air cleaner assembly is disclosed. The filter cartridge can include a media pack configured for installation into an air cleaner housing, the media pack extending along a longitudinal axis between opposite inlet and outlet flow ends, the media pack defining an outer perimeter. The filter cartridge can also include a circumferential shell surrounding at least a portion of the media pack outer perimeter. A radial flange extending from the circumferential shell proximate the media pack inlet end can also be provided. The flange can define a plurality of openings that are configured to receive protrusions on a housing body of the air cleaner assembly. The interaction between the protrusions and openings operates to ensure a secure seal between the housing body and the seal member.