Invention Grant
- Patent Title: Bicyclic heterocyclyl derivatives as IRAK4 inhibitors
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Application No.: US18141008Application Date: 2023-04-28
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Publication No.: US11981685B2Publication Date: 2024-05-14
- Inventor: Venkateshwar Rao Gummadi , Susanta Samajdar
- Applicant: Aurigene Oncology Limited
- Applicant Address: IN Bangalore
- Assignee: Aurigene Oncology Limited
- Current Assignee: Aurigene Oncology Limited
- Current Assignee Address: IN Bangalore
- Agency: Foley Hoag LLP
- Agent David P. Halstead; Alexander J. Chatterley
- Priority: IN 8CHE2014 2014.01.13 IN 00CHE2014 2014.06.20
- Main IPC: C07D513/04
- IPC: C07D513/04 ; C07D498/04 ; C07D519/00

Abstract:
The present invention provides bicyclic heterocyclyl kinase enzyme inhibitor compounds of formula (I), which are therapeutically useful as kinase inhibitors, particularly IRAK4 inhibitors.
wherein A, Y, Z, X1, X2, X3, R1, R3, ‘m’, ‘n’ and ‘p’ have the meanings given in the specification and pharmaceutically acceptable salts or stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical compositions comprising at least one of the compounds of compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
wherein A, Y, Z, X1, X2, X3, R1, R3, ‘m’, ‘n’ and ‘p’ have the meanings given in the specification and pharmaceutically acceptable salts or stereoisomers thereof that are useful in the treatment and prevention of diseases or disorders, in particular their use in diseases or disorders mediated by kinase enzyme, particularly IRAK4 enzyme. The present invention also provides pharmaceutical compositions comprising at least one of the compounds of compound of formula (I) together with a pharmaceutically acceptable carrier, diluent or excipient therefor.
Public/Granted literature
- US20230331740A1 BICYCLIC HETEROCYCLYL DERIVATIVES AS IRAK4 INHIBITORS Public/Granted day:2023-10-19
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