Invention Grant
- Patent Title: Methods for nucleic acid sequencing by tunneling recognition
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Application No.: US18124455Application Date: 2023-03-21
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Publication No.: US11981963B2Publication Date: 2024-05-14
- Inventor: Yann Astier
- Applicant: Roche Sequencing Solutions, Inc.
- Applicant Address: US CA Pleasanton
- Assignee: Roche Sequencing Solutions, Inc.
- Current Assignee: Roche Sequencing Solutions, Inc.
- Current Assignee Address: US CA Pleasanton
- Agency: Kilpatrick Townsend and Stockton LLP
- Main IPC: C12Q1/6869
- IPC: C12Q1/6869 ; G01N27/327 ; G01N33/487

Abstract:
Methods for analyzing a nucleic acid molecule are described. Methods may include attaching the nucleic acid molecule to a particle having a first characteristic dimension. In addition, methods may include applying an electric field through an aperture to move the particle to the aperture. Also, methods may include applying a voltage across a first electrode and a second electrode. Further, methods may include contacting a portion of the nucleic acid molecule to both the first electrode and the second electrode within the aperture, where the portion may include a nucleotide. In addition, methods may include measuring a current through the first electrode, the portion of the nucleic acid molecule, and the second electrode, where the measured current runs in a direction parallel to a longitudinal axis of the aperture. Also, methods may include identifying the nucleotide of the portion of the nucleic acid molecule based on the current.
Public/Granted literature
- US20230250475A1 METHODS FOR NUCLEIC ACID SEQUENCING BY TUNNELING RECOGNITION Public/Granted day:2023-08-10
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