Embodiments include methods and devices for per layer motion adaptive over-drive strength control for a display panel. Various embodiments may include determining motion information associated with a frame layer, determining an over-drive strength factor for the frame layer based at least in part on the motion information associated with the frame layer, and determining whether the over-drive strength factor is associated with computing a content difference. Various embodiments may include, in response to determining that the over-drive strength factor is associated with computing a content difference, performing fragment shading on the framebuffer object for the frame layer to generate an over-drive compensated framebuffer object for the frame layer based at least in part on the over-drive strength factor, and outputting the over-drive compensated framebuffer object for the frame layer to a default framebuffer for rendering on the display panel.