A re-closable wound dressing is provided. A base layer is operable to be attached to a skin of a patient. The base layer forms a pre-fabricated aperture through which a wound of the patient is accessible. A cover layer is coupled with the base layer. The cover layer is operable to cover the pre-fabricated aperture, and is permanently adhered to the base layer along at least a portion of the cover layer. The base layer and the cover layer are made of like materials.