A cargo handling system that utilizes a distributed antenna system for a cargo bay or compartment is disclosed. A cargo deck within the cargo bay may incorporate a plurality of power drive units. A mobile cargo controller may wirelessly communicate with the distributed antenna system to control movement of a ULD into/out of/within the cargo bay. A base station may be operatively interconnected with both the distributed antenna system and the plurality of power drive units (e.g., directly or indirectly via a control system, such as a control panel).