Invention Grant
- Patent Title: Polymeric forms of H-NOX proteins
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Application No.: US17397577Application Date: 2021-08-09
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Publication No.: US11987614B2Publication Date: 2024-05-21
- Inventor: Gregory Kapp , Laura Serwer , Natacha Le Moan , Stephen P. L. Cary
- Applicant: Omniox, Inc.
- Applicant Address: US CA San Carlos
- Assignee: OMNIOX, INC.
- Current Assignee: OMNIOX, INC.
- Current Assignee Address: US CA San Carlos
- Agency: Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.
- The original application number of the division: US16450913 2019.06.24
- Main IPC: C07H21/00
- IPC: C07H21/00 ; A61K38/16 ; A61K38/41 ; A61K45/06 ; A61N5/10 ; C07K14/795 ; G01N33/53 ; G01N33/574 ; A61K38/00
Abstract:
The invention provides polymeric H-NOX proteins for the delivery of oxygen with longer circulation half-lives compared to monomeric H-NOX proteins. Polymeric H-NOX proteins extravasate into and preferentially accumulate in tumor tissue for sustained delivery of oxygen. The invention also provides the use of H-NOX proteins as radiosensitizers for the treatment of brain cancers.
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