Invention Grant
- Patent Title: Biomarker pairs for predicting preterm birth
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Application No.: US17189048Application Date: 2021-03-01
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Publication No.: US11987846B2Publication Date: 2024-05-21
- Inventor: John Jay Boniface , Andrew Gassman , Jeff Flick , Chad Bradford , Ashoka Polpitiya , Tracey Cristine Fleischer , Durlin Edward Hickok , Paul Kearney , Gregory Charles Critchfield
- Applicant: Sera Prognostics, Inc.
- Applicant Address: US UT Salt Lake City
- Assignee: Sera Prognostics, Inc.
- Current Assignee: Sera Prognostics, Inc.
- Current Assignee Address: US UT Salt Lake City
- Agency: Greenberg Traurig, LLP
- Main IPC: C12Q1/6883
- IPC: C12Q1/6883 ; C07K14/47 ; G01N33/68
Abstract:
The disclosure provides a pair of isolated biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1, wherein the pair of biomarkers exhibits a change in reversal value between pregnant females at risk for pre-term birth and term controls. Also provided is a method of determining probability for preterm birth in a pregnant female, the method comprising measuring in a biological sample obtained from the pregnant female a reversal value for at least one pair of biomarkers selected from the group consisting of IBP4/SHBG, IBP4/PSG3, IBP4/LYAM1, IBP4/IGF2, CLUS/IBP3, CLUS/IGF2, CLUS/LYAM1, INHBC/PSG3, INHBC/IGF2, PSG2/LYAM1, PSG2/IGF2, PSG2/LYAM1, PEDF/PSG3, PEDF/SHBG, PEDF/LYAM1, CD14/LYAM1, and APOC3/LYAM1 to determine the probability for preterm birth in the pregnant female.
Public/Granted literature
- US20210180135A1 BIOMARKER PAIRS FOR PREDICTING PRETERM BIRTH Public/Granted day:2021-06-17
Information query
