Systems, methods, and non-transitory computer readable media are disclosed for enabling users to alter website presentations based on selected web accessibility profiles. In one implementation, an accessibility graphical user interface (GUI) for a website is displayed. A selection of one of the plurality of web accessibility profiles included in the GUI is received. A first and second predefined adjustments to website display parameters associated with the selected web accessibility profile are identified and initiated. The initiation of the first change and the second change is configured to transform a presentation of the website to conform with needs of a user having the disability associated with the selected web accessibility profile.