Systems and methods for selectively processing image studies with an artificial intelligence system. One system includes an electronic processor configured to select an image study awaiting review and update a workflow status of the image study to a first status indicating that the image study has been claimed for review by the artificial intelligence system. The electronic processor is also configured to apply at least one of the plurality of rules to the image study to determine whether the image study is applicable for processing by the artificial intelligence system, and, in response to determining the image study is not applicable for processing by the artificial intelligence system based on the at least one of the plurality of rules, update the workflow status associated with the image study to a second status to make the image study available for claiming by a manual reviewer or another artificial intelligence system.