Invention Grant
- Patent Title: Compositions and methods for promoting the mineralization of biological tissue
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Application No.: US16368042Application Date: 2019-03-28
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Publication No.: US11992517B2Publication Date: 2024-05-28
- Inventor: Matthew E. Cunningham , Agata Krzyzanowska
- Applicant: NEW YORK SOCIETY FOR THE RUPTURED AND CRIPPLED MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY
- Applicant Address: US NY New York
- Assignee: NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY
- Current Assignee: NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY
- Current Assignee Address: US NY New York
- Agency: Leason Ellis LLP
- Main IPC: C12N5/077
- IPC: C12N5/077 ; A61K9/00 ; A61K31/195 ; A61K31/675 ; A61K31/7076 ; A61K31/7088 ; A61K31/713 ; A61K35/32 ; A61K38/19 ; A61K38/20 ; A61K38/46 ; A61K39/00 ; A61K45/06 ; A61K48/00 ; A61L27/36 ; A61L27/38 ; A61L27/54 ; A61L27/58 ; A61P19/02 ; C07K14/47 ; C12N5/10 ; C12N15/11 ; C12N15/113 ; C12N15/55 ; C12N15/86
Abstract:
This invention relates to compositions and methods for activating and promoting mineralization in tissue that does not normally mineralize, specifically intervertebral discs. The composition comprises agents that increase the expression of the gene that encodes TNAP and/or the activation, amount or activity of TNAP protein, and agents that decrease the expression of ANK and/or ENPP and/or the activation, amount or activity of these proteins. The composition can be in the form of a cell or cells. The invention also relates to methods of using the composition.
Public/Granted literature
- US20190282672A1 COMPOSITIONS AND METHODS FOR PROMOTING THE MINERALIZATION OF BIOLOGICAL TISSUE Public/Granted day:2019-09-19
Information query
