Invention Grant
- Patent Title: Compositions comprising R-Spondin (RSPO) surrogate molecules
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Application No.: US16476501Application Date: 2018-01-11
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Publication No.: US11993645B2Publication Date: 2024-05-28
- Inventor: Vincent Christopher Luca , Kenan Christopher Garcia
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Bozicevic, Field & Francis LLP
- Agent Pamela J. Sherwood
- International Application: PCT/US2018/013325 2018.01.11
- International Announcement: WO2018/132572A 2018.07.19
- Date entered country: 2019-07-08
- Main IPC: C07K16/18
- IPC: C07K16/18 ; A61K38/00 ; C07K14/54 ; C07K14/55
Abstract:
R-spondin (RSPO) surrogate compositions and methods for their use are provided. RSPO surrogates of the invention comprise (i) a specific binding domain for Ring Finger Protein 43 (RNF43) or Zinc and Ring Finger Protein 3 (ZNRF3) and (ii) a cell targeting domain More specifically, wherein the specific binding domain for RNF43 or ZNRF3 is an antibody fragment, and wherein the cell targeting domain is a cytokine.
Public/Granted literature
- US20200024338A1 R-Spondin (RSPO) Surrogate Molecules Public/Granted day:2020-01-23
Information query
