An image compression method includes: obtaining a grayscale pixel information of an original image, wherein the grayscale pixel information comprises a plurality of sub-grayscale pixel information; scanning the plurality of sub-grayscale pixel information according to a preset first scanning sequence to obtain a first target grayscale pixel information; dividing the first target grayscale pixel information into a plurality of first grayscale areas according to a preset first grayscale difference threshold to generate a first area information; and compressing the sub-grayscale pixel information of each first grayscale area according to the first minimum grayscale pixel value, the first area label, and the plurality of sub-grayscale pixel information, to obtain a first compressed data of the original image. An image compression device, a computer device, and a computer readable storage medium are also provided.