An electronic cigarette has a mouthpiece portion and a power supply portion. The mouthpiece portion has an atomizer seating to receive an atomizer. An atomizer lock is located in the atomizer seating and is moveable between an open position and a locked position. An ejection mechanism with a biased ejection surface is moveable within the atomizer seating and is biased toward an extended position. The ejection mechanism is moved to a retracted position when an atomizer is introduced to the atomizer seating; the atomizer lock grips the atomizer to hold it in a fixed position. The atomizer is ejected from the atomizer seat when the atomizer lock is opened.