Described are systems, devices, and methods useful in the prevention and/or detection of liquid intrusion into ultrasound equipment. Ultrasound transducers and associated ultrasound circuitry, which can be located in an interior of an ultrasound system or device can be adversely affected by exposure to liquids. As described herein, ultrasound systems and devices can comprise a multilayer seal, for example, wherein the multilayer seal comprises one or more layers for preventing liquid intrusion and one or more layers for detection of liquid intrusion (e.g., wherein the one or more layers for detection of liquid intrusion comprise an indicator material capable of changing color when exposed to a liquid).