Invention Grant
- Patent Title: Two-part nitric oxide generating topical compositions
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Application No.: US16976382Application Date: 2019-02-28
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Publication No.: US11998513B2Publication Date: 2024-06-04
- Inventor: Joshua C. Doverspike , James Phan , Jianfeng Wu , Chuanwu Xi , Yu Qin , Mark E. Meyerhoff , Yang Zhou
- Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
- Applicant Address: US MI Ann Arbor
- Assignee: The Regents of the University of Michigan
- Current Assignee: The Regents of the University of Michigan
- Current Assignee Address: US MI Ann Arbor
- Agency: Dierker & Kavanaugh, P.C.
- International Application: PCT/US2019/019988 2019.02.28
- International Announcement: WO2019/169092A 2019.09.06
- Date entered country: 2020-08-27
- Main IPC: A61K31/04
- IPC: A61K31/04 ; A61K31/198 ; A61K33/30 ; A61K38/06 ; A61K47/06 ; B01J23/72 ; B01J31/02 ; A61K9/00 ; A61K9/06
Abstract:
A two-part topical composition includes a first composition including a S-nitrosothiol nitric oxide donor and a carrier, and a second composition including zinc oxide. The second composition is to be mixed with the first composition. The zinc oxide reacts with the S-nitrosothiol nitric oxide donor at a temperature ranging from about 20° C. to about 40° C. to enhance a rate of release of nitric oxide from a mixture of the first composition and the second composition.
Information query
