Invention Grant
- Patent Title: Substituted aminoquinolones as DGKalpha inhibitors for immune activation
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Application No.: US18072490Application Date: 2022-11-30
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Publication No.: US11998539B2Publication Date: 2024-06-04
- Inventor: Norbert Schmees , Lars Wortmann , Dennis Kirchhoff , Thi Thanh Uyen Nguyen , Nicolas Werbeck , Ulf Bömer , Kirstin Petersen , Christina Kober , Christian Lechner , Dirk Kosemund , Rienk Offringa , Mareike Grees , Benjamin Bader
- Applicant: Bayer Aktiengesellschaft , Bayer Pharma Aktiengesellschaft , Deutsches Krebsforschungszentrum
- Applicant Address: DE Leverkusen
- Assignee: BAYER AKTIENGESELLSCHAFT,BAYER PHARMA AKTIENGESELLSCHAFT,DEUTSCHES KREBSFORSCHUNGSZENTRUM
- Current Assignee: BAYER AKTIENGESELLSCHAFT,BAYER PHARMA AKTIENGESELLSCHAFT,DEUTSCHES KREBSFORSCHUNGSZENTRUM
- Current Assignee Address: DE Leverkusen; DE Berlin; DE Heidelberg
- Agency: MORRISON & FOERSTER LLP
- Priority: EP 212252 2019.11.28 EP 181065 2020.06.19
- Main IPC: A61K31/4545
- IPC: A61K31/4545 ; A61K31/4709 ; A61K31/4725 ; A61K31/496 ; A61K31/498 ; A61K31/55 ; A61K45/06 ; A61P35/00 ; A61P37/04 ; C07D401/04 ; C07D401/14 ; C07D405/14 ; C07D413/14 ; C07D417/14

Abstract:
The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.
Public/Granted literature
- US20230201186A1 SUBSTITUTED AMINOQUINOLONES AS DGKALPHA INHIBITORS FOR IMMUNE ACTIVATION Public/Granted day:2023-06-29
Information query
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