Invention Grant
- Patent Title: Conjugate of a tubulysin analog with branched linkers
-
Application No.: US16759175Application Date: 2017-12-31
-
Publication No.: US11998584B2Publication Date: 2024-06-04
- Inventor: Robert Yongxin Zhao , Qingliang Yang , Yuanyuan Huang , Linyao Zhao , Shun Gai , Hangbo Ye , Jun Lei , Yifang Xu , Mingjun Cao , Huihui Guo , Junxiang Jia , Qianqian Tong , Wenjun Li , Xiaomai Zhou , Hongsheng Xie , Lu Bai , Xiang Cai , Xiaotao Zhuo , Xiuzheng Zhang , Jun Zheng
- Applicant: Hangzhou DAC Biotech Co., Ltd.
- Applicant Address: CN Hangzhou
- Assignee: Hangzhou DAC Biotech Co., Ltd.
- Current Assignee: Hangzhou DAC Biotech Co., Ltd.
- Current Assignee Address: CN Hangzhou
- Agency: BUCHANAN, INGERSOLL & ROONEY PC
- International Application: PCT/CN2017/120454 2017.12.31
- International Announcement: WO2019/127607A 2019.07.04
- Date entered country: 2020-04-24
- Main IPC: A61K38/07
- IPC: A61K38/07 ; A61K45/06 ; C07K5/117
Abstract:
The present invention relates to the conjugation of a tubulysin analog compound to a cell-binding molecule with branched/side-chain linkers for having better delivery of the conjugate compound and targeted treatment of abnormal cells. It also relates to a branched-linkage method of conjugation of a tubulysin analog molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and autoimmune disease.
Public/Granted literature
- US20200276261A1 A CONJUGATE OF A TUBULYSIN ANALOG WITH BRANCHED LINKERS Public/Granted day:2020-09-03
Information query
IPC分类:
