Methods and devices for reducing inflammation, reducing pro-inflammatory cytokines molecules and increasing anti-inflammatory signaling molecules in a mammal is provided. In at least one embodiment, a device comprising, a power supply; an amplifier; an antenna and a waveform generator is provided and the one or more signals have an aperiodic continuous waveform function or an aperiodic pulse train that reduce inflammation, reduce pro-inflammatory cytokines molecules and/or increases anti-inflammatory signaling molecules in a mammal.