Invention Grant
- Patent Title: WDR5 inhibitors and modulators
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Application No.: US17287492Application Date: 2019-10-24
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Publication No.: US11999716B2Publication Date: 2024-06-04
- Inventor: Taekyu Lee , Joseph R. Alvarado , Jianhua Tian , Kenneth M. Meyers , Changho Han , Jonathan J. Mills , Kevin B. Teuscher , Shaun R. Stauffer , Stephen W. Fesik , Rocco D. Gogliotti
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Michael Best & Friedrich LLP
- International Application: PCT/US2019/057877 2019.10.24
- International Announcement: WO2020/086857A 2020.04.30
- Date entered country: 2021-04-21
- Main IPC: C07D401/14
- IPC: C07D401/14 ; C07D217/16 ; C07D401/06 ; C07D405/14 ; C07D413/06 ; C07D413/14 ; C07D417/06 ; C07D417/14 ; C07D487/04
Abstract:
Isoquinolinone compounds and derivatives inhibit WDR5 and associated protein-protein interactions, and the compounds and their pharmaceutical compositions are useful for treating disorders and conditions in a subject, such as cancer cell proliferation.
Public/Granted literature
- US20230012362A1 WDR5 INHIBITORS AND MODULATORS Public/Granted day:2023-01-12
Information query
