Invention Grant
- Patent Title: Method for producing diarylpyridine derivatives
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Application No.: US17252469Application Date: 2019-07-03
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Publication No.: US11999724B2Publication Date: 2024-06-04
- Inventor: Yuichi Aki , Fumihiko Toriyama , Natsuki Sakurai , Ai Kameda , Tomokazu Ogura
- Applicant: Daiichi Sankyo Company, Limited
- Applicant Address: JP Tokyo
- Assignee: Daiichi Sankyo Company, Limited
- Current Assignee: Daiichi Sankyo Company, Limited
- Current Assignee Address: JP Tokyo
- Agency: Fish & Richardson P.C.
- Priority: JP 18127197 2018.07.04
- International Application: PCT/JP2019/026395 2019.07.03
- International Announcement: WO2020/009132A 2020.01.09
- Date entered country: 2020-12-15
- Main IPC: C07D405/14
- IPC: C07D405/14 ; B01J23/44 ; C07D319/12 ; C07D405/12

Abstract:
The present invention relates to a novel method for producing diarylpyridine derivatives, and the object of the present invention is to provide a novel, industrially useful method. The present inventors developed a novel method for synthesizing pyridine rings without using palladium, a strong base, or a high-temperature reaction. In particular, they successfully developed a method that can be used to synthesize iminium salts as intermediates, synthesize cyano compounds from these iminium salts, and cyclize the cyano compounds into pyridines under very mild reaction conditions.
Public/Granted literature
- US20210188823A1 Method for Producing Diarylpyridine Derivatives Public/Granted day:2021-06-24
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