Invention Grant
- Patent Title: Human mesothelin chimeric antigen receptors and uses thereof
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Application No.: US16750951Application Date: 2020-01-23
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Publication No.: US11999794B2Publication Date: 2024-06-04
- Inventor: Gregory Beatty , Boris Engels , Neeraja Idamakanti , Carl H. June , Andreas Loew , Huijuan Song , Qilong Wu
- Applicant: Novartis AG , The Trustees of the University of Pennsylvania
- Applicant Address: CH PA Basel
- Assignee: Novartis AG,The Trustees of the University of Pennsylvania
- Current Assignee: Novartis AG,The Trustees of the University of Pennsylvania
- Current Assignee Address: CH Basel; US PA Philadelphia
- Agency: Saul Ewing LLP
- Agent Kathryn Doyle
- Priority: WO TCN2013089979 2013.12.19 WO TCN2014082610 2014.07.21 WO TCN2014090509 2014.11.06
- Main IPC: C07K16/30
- IPC: C07K16/30 ; A61K31/436 ; A61K38/00 ; A61K38/17 ; A61K39/00 ; A61K39/395 ; A61K48/00 ; C07K14/705 ; C07K14/715 ; C07K14/725 ; C12N5/0783 ; C12N15/85 ; C12N15/86
Abstract:
Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided are a chimeric antigen receptor (CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. Further provided are methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain.
Information query
