Invention Grant
- Patent Title: Modification of 5-methylcytosine catalyzed by Cmd1 enzyme and application thereof
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Application No.: US16327521Application Date: 2017-08-24
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Publication No.: US11999998B2Publication Date: 2024-06-04
- Inventor: Guoliang Xu
- Applicant: Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
- Applicant Address: CN Shanghai
- Assignee: Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
- Current Assignee: Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences
- Current Assignee Address: CN Shanghai
- Agency: Banner & Witcoff, Ltd.
- Priority: CN 1610719692.4 2016.08.24
- International Application: PCT/CN2017/098786 2017.08.24
- International Announcement: WO2018/036537A 2018.03.01
- Date entered country: 2019-03-15
- Main IPC: C12Q1/6869
- IPC: C12Q1/6869 ; C12N9/02 ; C12P19/34
Abstract:
The present invention relates to a novel modification of a 5-methylcytosine nucleic acid catalyzed by a Cmd1 enzyme and an application thereof. The present inventors have for the first time discovered Cmd1, a 5mC-modifying enzyme, which can link a glyceryl group to a 5mC methyl carbon of a methylated nucleic acid through a carbon-carbon single bond, and this is a new epigenetic modification.
Public/Granted literature
- US20230183795A1 Novel Modification of 5-Methylcytosine Catalyzed by CMD1 Enzyme and Application Thereof Public/Granted day:2023-06-15
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