A pressure compensation device with an accumulator group for controlled pressure drilling includes an electrical flat valve, a check valve, an accumulator group, a flanged pup joint and a support base. The electrical flat valve is connected to the check valve and is mounted on a top surface of the support base. The accumulator group mounted on the whole support base is a pre-storage pressure compensation device for controlled pressure drilling, and is located at a downstream position of the check valve. The liquid inlet end of the accumulator group is connected to the check valve, and the liquid discharge end is connected to the flanged pup joint.