New and/or alternative approaches to physical plant performance control that can account for the health of the physical plant. In one example, a control algorithm is enhanced by inclusion of terms related to optimized performance and terms related to physical plant health. In another example, a performance optimized control solution is determined, a maximum allowed deviation is defined, and a final solution for physical plant control is determined taking into account health factors to minimize health impacts within the maximum allowed deviation from optimized performance, using for example a two-stage analysis. Another example uses a two level system with a low level controller and a supervisory controller, in which the supervisory controller observes health impacts of ongoing operations managed by the low level controller, and modifies one or more parameters used by the low level controller.